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45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation

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semaglutide (Ozempic) for weight loss, published in JAMA Internal Medicine

doi: 10.1016/j.psyneuen.2015.11.021 10 AstrupA.RossnerS.Van GaalL.RissanenA.NiskanenL.Al HakimM.et al